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Mal-Val-Ala-PAB-N(SO2Me)-Exatecan

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Catalog No. T88689Cas No. 2575682-08-3

Compound LE14, or Mal-Val-Ala-PAB-N(SO2Me)-Exatecan, is a conjugate of the ADC toxin Exatecan and the linker Mal-Val-Ala-PAB-N(SO2Me). This compound is utilized in the synthesis of ADC FZ-AD005. FZ-AD005 is an ADC targeting delta-like ligand 3 (DLL3, KD=58.3 pM) and exhibits antitumor activity against SCLC cancer.

Mal-Val-Ala-PAB-N(SO2Me)-Exatecan

Mal-Val-Ala-PAB-N(SO2Me)-Exatecan

😃Good
Catalog No. T88689Cas No. 2575682-08-3
Compound LE14, or Mal-Val-Ala-PAB-N(SO2Me)-Exatecan, is a conjugate of the ADC toxin Exatecan and the linker Mal-Val-Ala-PAB-N(SO2Me). This compound is utilized in the synthesis of ADC FZ-AD005. FZ-AD005 is an ADC targeting delta-like ligand 3 (DLL3, KD=58.3 pM) and exhibits antitumor activity against SCLC cancer.
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Bioactivity
Description
Compound LE14, or Mal-Val-Ala-PAB-N(SO2Me)-Exatecan, is a conjugate of the ADC toxin Exatecan and the linker Mal-Val-Ala-PAB-N(SO2Me). This compound is utilized in the synthesis of ADC FZ-AD005. FZ-AD005 is an ADC targeting delta-like ligand 3 (DLL3, KD=58.3 pM) and exhibits antitumor activity against SCLC cancer.
Chemical Properties
Molecular Weight1141.22
FormulaC56H65FN8O15S
Cas No.2575682-08-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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