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Methoxy-X04

Name: Methoxy-X04
Brand: TargetMol
SKU: T22972
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22972Cas No. 863918-78-9

Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).

Methoxy-X04

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Purity: 97.01%

Catalog No. T22972Cas No. 863918-78-9

Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).

Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$76	In Stock
10 mg	$132	In Stock
25 mg	$263	In Stock
50 mg	$463	In Stock
100 mg	$683	In Stock
500 mg	$1,450	In Stock

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Purity:97.01%

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COA HPLC HNMR

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Product Introduction

Bioactivity

Description	Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).
In vitro	In in vitro binding studies, compared with Chrysamine-G (Ki = 25.3 nM), Methoxy-X04 exhibited similar binding affinity for Aβ fibrils (Ki = 26.8 nM) [1]. On brain slices of 12-month-old APP-PS1 (dE9) mice, 145 μM Methoxy-X04 was used for labeling fibrillary amyloid deposits [3].
In vivo	In PS1/APP mice, a single i.v. injection of 5 to 10 mg/kg Methoxy-X04 distinguished individual plaques from brain fluorescent images, within 30 to 60 min after treatment. A single i.p. injection of 10 mg/kg Methoxy-X04 also produced high contrast images of plaques and cerebrovascular amyloid in PS1/APP mouse brains [1].

Chemical Properties

Molecular Weight	344.4
Formula	C₂₃H₂₀O₃
Cas No.	863918-78-9
Smiles	COc1cc(\C=C\c2ccc(O)cc2)ccc1\C=C\c1ccc(O)cc1
Relative Density.	1.244 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 3.44 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9036 mL	14.5180 mL	29.0360 mL	145.1800 mL
5 mM	0.5807 mL	2.9036 mL	5.8072 mL	29.0360 mL
10 mM	0.2904 mL	1.4518 mL	2.9036 mL	14.5180 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

Methoxy-X-04Methoxy-X04MethoxyX04Methoxy X04