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Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective anticancer compound targeting microtubule proteins. It disrupts microtubule stability, inhibiting microtubule polymerization. This agent causes human tumor cells to arrest in the G0/G1 phase and induces apoptosis (Apoptosis) through activation of the Caspase cascade pathway. Additionally, it exhibits anti-inflammatory properties, inhibiting the production of TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 also suppresses tumor growth in xenograft mice.
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50 mg | Inquiry | Backorder |
Description | Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective anticancer compound targeting microtubule proteins. It disrupts microtubule stability, inhibiting microtubule polymerization. This agent causes human tumor cells to arrest in the G0/G1 phase and induces apoptosis (Apoptosis) through activation of the Caspase cascade pathway. Additionally, it exhibits anti-inflammatory properties, inhibiting the production of TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 also suppresses tumor growth in xenograft mice. |
In vitro | Microtubule destabilizing agent-2 (48 h) exhibits selective antiproliferative activity against human leukemia cells K-562 with an IC 50 of 3.27 μM, as compared to IC 50 values of 82.46 μM for MCF-7 and 31.27 μM for MDA-MB-231. |
In vivo | Microtubule destabilizing agent-2 (20-80 mg/kg, oral, 28 days) exhibits moderate to low anticancer activity in the K562 xenograft mouse model. |
Molecular Weight | 402.48 |
Formula | C26H26O4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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