MK2-IN-6

Name: MK2-IN-6
Brand: TargetMol
SKU: T89631
Price: 33 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T89631

MK2-IN-6 (Compound 11) is an effective and selective irreversible inhibitor of MK2 with an IC50 value of 2.3 nM. It suppresses the kinase activity of MK2, leading to sustained inhibition of MK2 signaling and reduction of pathological inflammatory factors in macrophages. MK2-IN-6 is capable of inhibiting the M2-like protein phenotype in macrophages both in vitro and in vivo, showing potential for use in colorectal cancer research.

MK2-IN-6

Catalog No. T89631

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Product Introduction

Bioactivity

Description	MK2-IN-6 (Compound 11) is an effective and selective irreversible inhibitor of MK2 with an IC50 value of 2.3 nM. It suppresses the kinase activity of MK2, leading to sustained inhibition of MK2 signaling and reduction of pathological inflammatory factors in macrophages. MK2-IN-6 is capable of inhibiting the M2-like protein phenotype in macrophages both in vitro and in vivo, showing potential for use in colorectal cancer research.
Targets&IC50	MK5:>100 nM, FGFR4:>1000 nM, MK3:>100 nM, TTK:>1000 nM, p70S6Kb:>1000 nM, p38:>1000 nM
In vitro	MK2-IN-6 exhibits high selectivity and irreversible inhibition of MK2, similar to PF-3644022, with an inhibitory concentration of 2.3 nM over 70 minutes. At concentrations ranging from 1-10 μM for 1.5 or 6 hours, MK2-IN-6 profoundly suppresses transcription and production of cytokines in macrophages by targeting classical downstream genes associated with MK2.
In vivo	Administered at a dosage of 10 mg/kg through intraperitoneal injection twice daily for a duration of 12 days, MK2-IN-6 significantly inhibited tumor growth in mice with the MC38 tumor model.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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