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MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively.
Description | MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively. |
Targets&IC50 | MMP9:13 μM (IC50), MMP13:1.8 μM (IC50), MMP2:6.6 μM (IC50), MMP1:10 μM (IC50) |
In vitro | MMPI-1154, at concentrations ranging from 1-100 μM, effectively inhibits the MMP-2 enzyme extracted from rat hearts in vitro, achieving complete inhibition at 100 μM[1]. At a concentration of 1 μM, MMPI-1154 demonstrates significant cardio-cytoprotection, markedly reducing infarct size in an ex vivo model of acute myocardial infarction[1]. |
Molecular Weight | 445.494 |
Formula | C26H24FN3O3 |
Cas No. | 1382722-47-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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