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MS-8709 is a G9a/GLP PROTAC Degrader (DC50(G9a) = 274 nM; DC50(GLP) = 260 nM) that induces G9a/GLP degradation in a concentration-, time-, and ubiquitin-proteasome system (UPS)-dependent manner. It shows higher selectivity for G9a/GLP over other methyltransferases, without affecting G9a/GLP mRNA expression. In addition, MS-8709 demonstrates superior inhibition of prostate cancer, leukemia, and lung cancer cell growth compared to its parent compound, the G9a/GLP inhibitor UNC0642, and possesses favorable murine pharmacokinetic properties for in vivo efficacy studies.
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10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | MS-8709 is a G9a/GLP PROTAC Degrader (DC50(G9a) = 274 nM; DC50(GLP) = 260 nM) that induces G9a/GLP degradation in a concentration-, time-, and ubiquitin-proteasome system (UPS)-dependent manner. It shows higher selectivity for G9a/GLP over other methyltransferases, without affecting G9a/GLP mRNA expression. In addition, MS-8709 demonstrates superior inhibition of prostate cancer, leukemia, and lung cancer cell growth compared to its parent compound, the G9a/GLP inhibitor UNC0642, and possesses favorable murine pharmacokinetic properties for in vivo efficacy studies. |
Alias | MS8709, MS 8709 |
Molecular Weight | 1200.57 |
Formula | C64H95F2N11O7S |
Cas No. | 3060730-06-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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