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MT1
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Catalog No. T39461Cas No. 2060573-82-0
MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).
MT1
😃Good
Catalog No. T39461Cas No. 2060573-82-0
MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | 827 € | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1). |
| In vitro | MT1 (100 nM, 24 h) prominently induces apoptosis in MV4;11 cells via caspase-3 and PARP pathways, evidenced by substantial caspase-3 and PARP cleavage in Western Blot Analysis [1]. |
| In vivo | MT1, administered intraperitoneally at doses of 44.2 and 22.1 μmol/kg daily for 14 days, significantly delayed the progression of leukemia in mice (Mus musculus) in comparison to the control, JQ1. Additionally, MT1 demonstrated a terminal half-life (t 1/2) of 2.70 hours in mice. In the context of leukemia xenograft models, this regimen markedly reduced the leukemic burden over the study period when compared to either the vehicle or JQ1. |
| Molecular Weight | 1134.2 |
| Formula | C54H66Cl2N10O9S2 |
| Cas No. | 2060573-82-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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