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N,N'-DME-N-PEG2-Boc

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Catalog No. T18459Cas No. 2279944-69-1

'N,N'-DME-N-PEG2-Boc is a PEG-based linker used in the formation of PROTAC molecules by connecting two essential ligands. This linker facilitates selective protein degradation through the ubiquitin-proteasome system within cells.

N,N'-DME-N-PEG2-Boc

N,N'-DME-N-PEG2-Boc

😃Good
Catalog No. T18459Cas No. 2279944-69-1
'N,N'-DME-N-PEG2-Boc is a PEG-based linker used in the formation of PROTAC molecules by connecting two essential ligands. This linker facilitates selective protein degradation through the ubiquitin-proteasome system within cells.
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2 mg$355 days
5 mg$535 days
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Product Introduction

Bioactivity
Description
'N,N'-DME-N-PEG2-Boc is a PEG-based linker used in the formation of PROTAC molecules by connecting two essential ligands. This linker facilitates selective protein degradation through the ubiquitin-proteasome system within cells.
In vitro
PROTACs consist of two ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight304.43
FormulaC15H32N2O4
Cas No.2279944-69-1
Relative Density.0.986 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PEGsN,N'-DME-N-PEG2-BocN,N'-DME-N-PEG-2-BocN,N'DMENPEG2BocN,N' DME N PEG2 Boc
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