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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $178 | 35 days | |
10 mg | $333 | 35 days | |
50 mg | $1,380 | 35 days | |
100 mg | $2,420 | 35 days |
Description | Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent. |
Molecular Weight | 441.6 |
Formula | C27H39NO4 |
Cas No. | 259143-19-6 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 30 mg/mL PBS (pH 7.2): 1 mg/mL Ethanol: 30 mg/mL DMSO: 30 mg/mL |
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