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N-(m-PEG4)-N'-(PEG3-Mal)-Cy5

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Catalog No. T18435

The compound N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

N-(m-PEG4)-N'-(PEG3-Mal)-Cy5

N-(m-PEG4)-N'-(PEG3-Mal)-Cy5

😃Good
Catalog No. T18435
The compound N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].
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Product Introduction

Bioactivity
Description
The compound N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].
In vitro
PROTACs consist of two ligands linked by a connector, with one ligand targeting an E3 ubiquitin ligase and the other targeting a specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade these target proteins[1].
Chemical Properties
Molecular Weight907.53
FormulaC49H67ClN4O10
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PEGsN(mPEG4)N'(PEG3Mal)Cy5N-(m-PEG4)-N'-(PEG3-Mal)-Cy5N-(m-PEG-4)-N'-(PEG3-Mal)-Cy5N (m PEG4) N' (PEG3 Mal) Cy5
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