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Naptumomab estafenatox

Naptumomab estafenatox
Naptumomab estafenatox (ABR-217620) is a fusion protein that combines an anti-5T4 antibody with a SEA/E-120 superantigen, categorized as a tumor targeting superantigen (TTS). It has potential applications in lung cancer research [1].
Catalog No. T9901A-045Cas No. 676258-98-3

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Naptumomab estafenatox

Catalog No. T9901A-045Cas No. 676258-98-3

Naptumomab estafenatox (ABR-217620) is a fusion protein that combines an anti-5T4 antibody with a SEA/E-120 superantigen, categorized as a tumor targeting superantigen (TTS). It has potential applications in lung cancer research [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Naptumomab estafenatox (ABR-217620) is a fusion protein that combines an anti-5T4 antibody with a SEA/E-120 superantigen, categorized as a tumor targeting superantigen (TTS). It has potential applications in lung cancer research [1].
In vitro
Naptumomab estafenatox (0.001-10000 pM; 4 hours) exhibits EC50 values against Staphylococcal enterotoxin A (SEA)-mediated T cell responses in Caki-2 and Raji cells of 20 and 30000 pM, respectively [1]. For SEA/E-120 mediated T cell responses, its EC50 values are 0.1 and 100000 pM for the same cell lines [1]. Additionally, naptumomab estafenatox (1 pM-1 μM; 4 days) promotes human lymphocyte proliferation in a dose-dependent manner [1]. Cell Proliferation Assay [1] Cell Line: Human peripheral blood mononuclear cell (PBMC) line Concentration: 1 pM-1 μM Incubation Time: 4 days Result: Induced proliferation of human PBMCs in a dose-dependent way, requiring higher concentrations compared to SEA wt (C242Fab-SEA) and anatumomab mafenatox.
In vivo
Naptumomab estafenatox (0.016 mg; intravenous injection, once daily for 8 days) exhibits antitumor activity in immunodeficient mice with Calu-1 tumors [1]. Animal Model: SCID mice implanted with Calu-1 tumors and injected with PBMCs [1]. Dosage: 0.016 mg via intravenous administration for 8 consecutive days. Result: Notably decreased tumor mass.
AliasANYARA, ABR-217620
Chemical Properties
Cas No.676258-98-3
Storage & Solubility Information
StorageShipping with blue ice.

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