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NDT-19795
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Catalog No. T86987Cas No. 2272917-12-9
NDT-19795 is a potent NLRP3 inflammasome inhibitor with an IC 50 value of 66 nM using the PBMC method and 4.7 μM using the WB method. It is a carboxylic acid-active compound that can be derived from NT-0796 within cells, and is applicable for neurological disease research [1].
NDT-19795
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Catalog No. T86987Cas No. 2272917-12-9
NDT-19795 is a potent NLRP3 inflammasome inhibitor with an IC 50 value of 66 nM using the PBMC method and 4.7 μM using the WB method. It is a carboxylic acid-active compound that can be derived from NT-0796 within cells, and is applicable for neurological disease research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NDT-19795 is a potent NLRP3 inflammasome inhibitor with an IC 50 value of 66 nM using the PBMC method and 4.7 μM using the WB method. It is a carboxylic acid-active compound that can be derived from NT-0796 within cells, and is applicable for neurological disease research [1]. |
| In vivo | Administered intravenously as a single dose of 3 mg/kg, NDT-19795 exhibits a brain-to-blood ratio of 0.07 in C57BL/6 mice, indicating low permeability across the blood-brain barrier [1]. |
| Molecular Weight | 367.40 |
| Formula | C20H21N3O4 |
| Cas No. | 2272917-12-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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