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NP-BTA

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Catalog No. T87032Cas No. 544420-99-7

NP-BTA, an allosteric inhibitor of glutaminyl-tRNA synthetase (GlnRS), demonstrates antifungal activity against Candida albicans, with a MIC50 of 6.25 μM [1].

NP-BTA

NP-BTA

😃Good
Catalog No. T87032Cas No. 544420-99-7
NP-BTA, an allosteric inhibitor of glutaminyl-tRNA synthetase (GlnRS), demonstrates antifungal activity against Candida albicans, with a MIC50 of 6.25 μM [1].
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Product Introduction

Bioactivity
Description
NP-BTA, an allosteric inhibitor of glutaminyl-tRNA synthetase (GlnRS), demonstrates antifungal activity against Candida albicans, with a MIC50 of 6.25 μM [1].
In vitro
NP-BTA (300 μM) inhibits GlnRS by binding with His6-Gln4 (K D of 180 nM), thereby preventing the aminoacylation of tRNA Gln, with an IC 50 of 106 nM [1].
In vivo
NP-BTA (0.096–0.27 g 2% NP-BTA cream, applied twice daily for 7 days) helps protect immunosuppressed CD-1 mice from infection by T. mentagrophytes conidia [1]. Animal Model: Immunosuppressed CD-1 mice infected with T. mentagrophytes [1] Dosage: 0.096–0.27 g 2% NP-BTA cream Administration: Topical application, twice daily for 7 days Result: Reduced fungal burden.
Chemical Properties
Molecular Weight231.27
FormulaC11H9N3OS
Cas No.544420-99-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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