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NPD6433

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Catalog No. T201532

NPD6433 is a triazole indole compound that exhibits broad-spectrum activity against all screened fungal strains. It targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH oxidase activity, thereby blocking the biosynthesis of essential fatty acids.

NPD6433

NPD6433

😃Good
Catalog No. T201532
NPD6433 is a triazole indole compound that exhibits broad-spectrum activity against all screened fungal strains. It targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH oxidase activity, thereby blocking the biosynthesis of essential fatty acids.
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Product Introduction

Bioactivity
Description
NPD6433 is a triazole indole compound that exhibits broad-spectrum activity against all screened fungal strains. It targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH oxidase activity, thereby blocking the biosynthesis of essential fatty acids.
Chemical Properties
Molecular Weight391.42
FormulaC21H21N5O3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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