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NR-160

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Catalog No. T37068Cas No. 2484895-50-1

NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.

NR-160

NR-160

😃Good
Catalog No. T37068Cas No. 2484895-50-1
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
Pack SizePriceAvailabilityQuantity
1 mgTBD35 days
5 mgTBD35 days
10 mgTBD35 days
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Product Introduction

Bioactivity
Description
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
Chemical Properties
Molecular Weight510.47
FormulaC25H21F3N6O3
Cas No.2484895-50-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 1 mg/mL (1.96 mM), Sonication is recommended.
DMSO: 20 mg/mL (39.18 mM), Sonication is recommended.
DMF: 30 mg/mL (58.77 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM1.9590 mL9.7949 mL19.5898 mL97.9489 mL
DMSO/DMF
1mg5mg10mg50mg
5 mM0.3918 mL1.9590 mL3.9180 mL19.5898 mL
10 mM0.1959 mL0.9795 mL1.9590 mL9.7949 mL
20 mM0.0979 mL0.4897 mL0.9795 mL4.8974 mL
DMF
1mg5mg10mg50mg
50 mM0.0392 mL0.1959 mL0.3918 mL1.9590 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

NR 160NR-160NR160
Related Tags: buy NR-160 | purchase NR-160 | NR-160 cost | order NR-160 | NR-160 chemical structure | NR-160 formula | NR-160 molecular weight
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