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NSC194598, a p53 DNA-binding inhibitor, demonstrates an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma TT cells and is utilized in research investigating acute toxicity in normal tissues due to radiation and chemotherapy [1] [2].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | 8-10 weeks | |
50 mg | Inquiry | 8-10 weeks |
Description | NSC194598, a p53 DNA-binding inhibitor, demonstrates an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma TT cells and is utilized in research investigating acute toxicity in normal tissues due to radiation and chemotherapy [1] [2]. |
Molecular Weight | 317.38 |
Formula | C20H19N3O |
Cas No. | 5358-76-9 |
Storage | Shipping with blue ice. |
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