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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $239 | 6-8 weeks | |
25 mg | $766 | 6-8 weeks | |
50 mg | $996 | 6-8 weeks | |
100 mg | $1,490 | 6-8 weeks |
Description | NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities |
In vitro | NSC745885 (0.5-4 μM; 24 hours) enhances annexin V positive cells in a dose-dependent manner, and the differences appear as a dose-dependent manner. NSC745885 (0.5-2 μM; 24 or 48 hours) reduces XIAP protein levels and increases protein levels both as a dose-dependent manner in SAS cells. NSC745885 (0.5-4 μM; 24, 48 or 72 hours) has a growth inhibitory or death-promoting effect on the SAS cells, it significantly decreases the densities of cultured cells when compared with untreated cells. The IC50 of NSC745885 is 0.85 μM after 72 hours' treatment [1]. |
In vivo | NSC745885 (intraperitoneal injection; 2 mg/kg; once daily; 10 days) treatment obviously decreases tumor size when compared with the vehicle control. It shows higher safety than doxorubicin[1]. |
Molecular Weight | 266.27 |
Formula | C14H6N2O2S |
Cas No. | 4219-52-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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