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NSC 194308
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Catalog No. T87038Cas No. 90379-42-3
NSC 194308, an enhancer of U2AF2-RNA complexes, promotes the association of the U2AF1-U2AF2-SF1-splice site RNA complex by targeting a site between U2AF2 RNA recognition motifs (RRM1 and RRM2). It inhibits pre-mRNA splicing by stalling spliceosome assembly at the stage where U2AF recruits U2 snRNP to the branchpoint. Additionally, NSC 194308 strengthens the binding of pre-mRNA to U2AF2, selectively inducing cell death in leukemia cell lines with spliceosome mutations [1].
NSC 194308
😃Good
Catalog No. T87038Cas No. 90379-42-3
NSC 194308, an enhancer of U2AF2-RNA complexes, promotes the association of the U2AF1-U2AF2-SF1-splice site RNA complex by targeting a site between U2AF2 RNA recognition motifs (RRM1 and RRM2). It inhibits pre-mRNA splicing by stalling spliceosome assembly at the stage where U2AF recruits U2 snRNP to the branchpoint. Additionally, NSC 194308 strengthens the binding of pre-mRNA to U2AF2, selectively inducing cell death in leukemia cell lines with spliceosome mutations [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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| Description | NSC 194308, an enhancer of U2AF2-RNA complexes, promotes the association of the U2AF1-U2AF2-SF1-splice site RNA complex by targeting a site between U2AF2 RNA recognition motifs (RRM1 and RRM2). It inhibits pre-mRNA splicing by stalling spliceosome assembly at the stage where U2AF recruits U2 snRNP to the branchpoint. Additionally, NSC 194308 strengthens the binding of pre-mRNA to U2AF2, selectively inducing cell death in leukemia cell lines with spliceosome mutations [1]. |
| Molecular Weight | 306.44 |
| Formula | C12H22N2O3S2 |
| Cas No. | 90379-42-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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