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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) represents the hemicalcium hydrate form of the calcium salt of Orforglipron, an orally active agonist targeting the Glucagon-like peptide-1 receptor (GLP-1R). This compound has demonstrated efficacy in mitigating type 2 diabetes [1]. |
In vivo | Orforglipron hemicalcium hydrate effectively inhibits food intake in cynomolgus monkeys, promotes insulin secretion, and reduces blood glucose levels when administered in a dose-dependent manner. In these models, doses of 0.05-1.35 mg/kg achieved peak plasma concentration (C max) approximately 2 hours post-administration, showing near-proportional increases in plasma exposure with dose. Pharmacokinetic analysis details the absorption process through the gastrointestinal tract, indicating dose-dependent characteristics. The compound was continuously administered intravenously for 30 minutes or via gavage for 5 days at specific concentrations, resulting in improved metabolic outcomes. |
Molecular Weight | 921.02 |
Formula | C48H48F2N10O5.1/2Ca.H2O |
Cas No. | 3008544-96-2 |
Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 6 months | Shipping with blue ice. |
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