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Pabinafusp alfa

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Catalog No. T81573Cas No. 2140211-48-7
Alias JR-141

Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accumulation within the central nervous system of mucopolysaccharidosis II (MPS II) mice. It enhances cognitive function and protects against neuronal damage in the central nervous system [1].

Pabinafusp alfa

Pabinafusp alfa

😃Good
Catalog No. T81573Alias JR-141Cas No. 2140211-48-7
Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accumulation within the central nervous system of mucopolysaccharidosis II (MPS II) mice. It enhances cognitive function and protects against neuronal damage in the central nervous system [1].
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Product Introduction

Bioactivity
Description
Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accumulation within the central nervous system of mucopolysaccharidosis II (MPS II) mice. It enhances cognitive function and protects against neuronal damage in the central nervous system [1].
In vivo
Pabinafusp alfa, administered intravenously at doses ranging from 0.1 to 2 mg/kg once weekly for 36 weeks, dose-dependently prevented neuropathological changes and ameliorated neurological deficits in an MPS II murine model [1].
AliasJR-141
Chemical Properties
Cas No.2140211-48-7
Storage & Solubility Information
Storagestore at -20°C | Shipping with blue ice.

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