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PAMAM Dendrimer G0.0 amine

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Catalog No. T203456Cas No. 155773-72-1

PAMAM Dendrimer G0.0 amine functions as a pore-forming channel antagonist, affecting anthrax toxin protective antigen 63 (PA63, IC50 of 231 nM) and Clostridium botulinum C2 toxin subunit (C2IIa, IC50 of 940 nM). At 10 and 20 µM concentrations, it reduces HeLa cell death induced by C2 toxin. Additionally, PAMAM Dendrimer G0.0 amine acts as a nickel chelator. When combined with a chitosan complex on polysulfone membranes, it selectively captures and stores carbon dioxide (CO2) in gas feed systems. It is utilized in synthesizing PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). This compound is applicable in research related to infection, cancer, and drug delivery systems.

PAMAM Dendrimer G0.0 amine

PAMAM Dendrimer G0.0 amine

😃Good
Catalog No. T203456Cas No. 155773-72-1
PAMAM Dendrimer G0.0 amine functions as a pore-forming channel antagonist, affecting anthrax toxin protective antigen 63 (PA63, IC50 of 231 nM) and Clostridium botulinum C2 toxin subunit (C2IIa, IC50 of 940 nM). At 10 and 20 µM concentrations, it reduces HeLa cell death induced by C2 toxin. Additionally, PAMAM Dendrimer G0.0 amine acts as a nickel chelator. When combined with a chitosan complex on polysulfone membranes, it selectively captures and stores carbon dioxide (CO2) in gas feed systems. It is utilized in synthesizing PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). This compound is applicable in research related to infection, cancer, and drug delivery systems.
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Product Introduction

Bioactivity
Description
PAMAM Dendrimer G0.0 amine functions as a pore-forming channel antagonist, affecting anthrax toxin protective antigen 63 (PA63, IC50 of 231 nM) and Clostridium botulinum C2 toxin subunit (C2IIa, IC50 of 940 nM). At 10 and 20 µM concentrations, it reduces HeLa cell death induced by C2 toxin. Additionally, PAMAM Dendrimer G0.0 amine acts as a nickel chelator. When combined with a chitosan complex on polysulfone membranes, it selectively captures and stores carbon dioxide (CO2) in gas feed systems. It is utilized in synthesizing PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). This compound is applicable in research related to infection, cancer, and drug delivery systems.
Chemical Properties
Molecular Weight516.68
FormulaC22H48N10O4
Cas No.155773-72-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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