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pan-KRAS-IN-6

Catalog No. T88001Cas No. 3033565-36-2

Pan-KRAS-IN-6 (compound 12) is a potent pan-KRAS inhibitor, with IC50 values of 9.79 nM for Kras G12D and 6.03 nM for Kras G12V.

pan-KRAS-IN-6

pan-KRAS-IN-6

Catalog No. T88001Cas No. 3033565-36-2
Pan-KRAS-IN-6 (compound 12) is a potent pan-KRAS inhibitor, with IC50 values of 9.79 nM for Kras G12D and 6.03 nM for Kras G12V.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
Pan-KRAS-IN-6 (compound 12) is a potent pan-KRAS inhibitor, with IC50 values of 9.79 nM for Kras G12D and 6.03 nM for Kras G12V.
Targets&IC50
KRas G12D:9.79 nM, KRas G12V:6.03 nM
In vitro
Pan-KRAS-IN-6 (20 nM; 72 h) demonstrates a strong inhibitory effect on the growth activity of ASPC-1 cells, with an IC 50 of 8.8 μm [1].
Chemical Properties
Molecular Weight635.10
FormulaC29H30ClF3N6O3S
Cas No.3033565-36-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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