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Pan-RAS-IN-2
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Catalog No. T88116Cas No. 3034673-92-9
Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS(ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects.
Pan-RAS-IN-2
😃Good
Catalog No. T88116Cas No. 3034673-92-9
Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS(ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 775 € | 4-6 weeks | |
| 5 mg | 1.596 € | 4-6 weeks | |
| 10 mg | 2.156 € | 4-6 weeks | |
| 25 mg | 3.201 € | 4-6 weeks | |
| 50 mg | 4.303 € | 4-6 weeks | |
| 100 mg | 5.823 € | 4-6 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS(ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects. |
| Molecular Weight | 837.08 |
| Formula | C46H60N8O5S |
| Cas No. | 3034673-92-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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