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PEG5-Tos

Name: PEG5-Tos
Brand: TargetMol
SKU: T16462
Price: 39 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16462Cas No. 155130-15-7

PEG5-Tos is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

PEG5-Tos

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Catalog No. T16462Cas No. 155130-15-7

Pack Size	Price	Availability	Quantity
100 mg	Inquiry	7-10 days
500 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	PEG5-Tos is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
In vitro	PROTACs, consisting of two ligands connected by a linker—one binding to an E3 ubiquitin ligase and the other to the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	392.46
Formula	C₁₇H₂₈O₈S
Cas No.	155130-15-7
Relative Density.	1.206 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 100 mg/mL (254.80 mM), Sonication is recommended.

DMSO: 100 mg/mL (254.80 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5480 mL	12.7402 mL	25.4803 mL	127.4015 mL
5 mM	0.5096 mL	2.5480 mL	5.0961 mL	25.4803 mL
10 mM	0.2548 mL	1.2740 mL	2.5480 mL	12.7402 mL
20 mM	0.1274 mL	0.6370 mL	1.2740 mL	6.3701 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL	2.5480 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PEG5 TosPEG5TosPEG5-TosPEG-5-Tos