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PF-05381941

Name: PF-05381941
Brand: TargetMol
SKU: T36017
Rating: 4.5 (1 reviews)

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Catalog No. T36017Cas No. 1474022-02-0

PF-05381941 is a potent dual inhibitor of TAK1/p38α, exhibiting IC50 values of 156 nM and 186 nM, respectively[1].

PF-05381941

😃Good

Catalog No. T36017Cas No. 1474022-02-0

PF-05381941 is a potent dual inhibitor of TAK1/p38α, exhibiting IC50 values of 156 nM and 186 nM, respectively[1].

Pack Size	Price	Availability
25 mg	$877	6-8 weeks
50 mg	$1,140	6-8 weeks
100 mg	$1,820	6-8 weeks

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Product Introduction

Bioactivity

Description	PF-05381941 is a potent dual inhibitor of TAK1/p38α, exhibiting IC50 values of 156 nM and 186 nM, respectively[1].
Targets&IC50	p38α:186 nM (IC50), TAK1:156 nM (IC50)
In vitro	PF-05381941 inhibits the LPS-stimulated release of TNF-α from human peripheral mononuclear (PMN) cells, with an IC50 of 8 nM [1].

Chemical Properties

Molecular Weight	466.53
Formula	C₂₇H₂₆N₆O₂
Cas No.	1474022-02-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (214.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1435 mL	10.7174 mL	21.4348 mL	107.1742 mL
5 mM	0.4287 mL	2.1435 mL	4.2870 mL	21.4348 mL
10 mM	0.2143 mL	1.0717 mL	2.1435 mL	10.7174 mL
20 mM	0.1072 mL	0.5359 mL	1.0717 mL	5.3587 mL
50 mM	0.0429 mL	0.2143 mL	0.4287 mL	2.1435 mL
100 mM	0.0214 mL	0.1072 mL	0.2143 mL	1.0717 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PF 05381941PF05381941PF-05381941