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PFM03
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Catalog No. T60621Cas No. 1558598-48-3
PFM03 is an inhibitor of MRE11 Endonuclease that regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1].
PFM03
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Catalog No. T60621Cas No. 1558598-48-3
PFM03 is an inhibitor of MRE11 Endonuclease that regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,100 | 6-8 weeks | |
| 50 mg | $1,430 | 6-8 weeks | |
| 100 mg | $2,170 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PFM03 is an inhibitor of MRE11 Endonuclease that regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1]. |
| In vitro | PFM03, when applied at concentrations ranging from 50 to 400 μM for a duration of 30 minutes, specifically inhibits the activity of MRE11 endonuclease [1]. Furthermore, at a concentration of 100 μM over 30 minutes, PFM03 facilitates normal double-strand break (DSB) repair in G2 phase cells marked by CENPF positivity [1]. Additionally, at a dose of 50 μM for an 8-hour period, PFM03 is observed to increase the utilization of non-homologous end-joining (NHEJ) mechanisms while concurrently decreasing homologous recombination (HR) in cells [1]. |
| Molecular Weight | 293.4 |
| Formula | C14H15NO2S2 |
| Cas No. | 1558598-48-3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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