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Phenyltoloxamine
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Catalog No. T60391Cas No. 92-12-6
Phenyltoloxamine (Bistrimin) is an antihistamine with sedative and analgesic properties, and it exhibits strong Sigma-1 receptor binding affinity with a Ki of 160 nM [1] [2] [3].
Phenyltoloxamine
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Catalog No. T60391Cas No. 92-12-6
Phenyltoloxamine (Bistrimin) is an antihistamine with sedative and analgesic properties, and it exhibits strong Sigma-1 receptor binding affinity with a Ki of 160 nM [1] [2] [3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Phenyltoloxamine (Bistrimin) is an antihistamine with sedative and analgesic properties, and it exhibits strong Sigma-1 receptor binding affinity with a Ki of 160 nM [1] [2] [3]. |
| In vitro | Phenyltoloxamine, within a concentration range of 10-50 μM over 24 hours, demonstrates cytotoxic effects on EVSA-T cells [2]. Additionally, it exhibits significant binding affinity for the Sigma 1 Receptor (S1R), with a K i value of 160 nM [3]. At a higher concentration of 100 μM, Phenyltoloxamine inhibits the CYP2D6 enzyme in human liver by 99.0% [4]. |
| Molecular Weight | 255.35 |
| Formula | C17H21NO |
| Cas No. | 92-12-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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