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Pilsicainide
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Catalog No. T60482Cas No. 88069-67-4
Pilsicainide (SUN 1165 free acid) is a potent class Ic antiarrhythmic agent and a sodium channel blocker[1][2].
Pilsicainide
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Catalog No. T60482Cas No. 88069-67-4
Pilsicainide (SUN 1165 free acid) is a potent class Ic antiarrhythmic agent and a sodium channel blocker[1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pilsicainide (SUN 1165 free acid) is a potent class Ic antiarrhythmic agent and a sodium channel blocker[1][2]. |
| In vitro | Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) dose-dependently reduces the peak amplitude of the net inward current, with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells [1]. |
| In vivo | Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) significantly reduces conduction velocity in the atrium of T4-treated male Sprague-Dawley rats (weighing 200-220 g) by decreasing Max dV/dt and net inward current, and altering electrocardiographic parameters. Administered as a bolus into the right external carotid vein over two minutes, pilsicainide extends the QT interval at 15 and 60 minutes post-administration, decreases the durations of P wave and QRS complex, reduces action potential amplitudes (APA) and Max dV/dt, and lengthens action potential duration. |
| Molecular Weight | 272.39 |
| Formula | C17H24N2O |
| Cas No. | 88069-67-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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