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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 1-2 weeks | |
50 mg | $1,980 | 1-2 weeks | |
100 mg | $2,500 | 1-2 weeks |
Description | Pilsicainide (SUN 1165 free acid) is a potent class Ic antiarrhythmic agent. Pilsicainide is a potent sodium channel blocker[1][2]. |
In vitro | Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) reduces the peak amplitude of the net inward current dose-dependently, exhibiting an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells [1]. |
In vivo | Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) effectively reduces the conduction velocity in the atrium of T 4-treated male Sprague-Dawley rats (weighing 200-220 g) by diminishing the Max dV/dt and the net inward current, as well as altering various electrocardiographic parameters. Administered as a bolus injection into the right external carotid vein over two minutes, pilsicainide notably extends the QT interval at both 15 and 60 minutes post-administration, decreases the durations of P wave and QRS complex, significantly reduces the action potential amplitudes (APA) and Max dV/dt, and lengthens the duration of the action potential. |
Molecular Weight | 272.39 |
Formula | C17H24N2O |
Cas No. | 88069-67-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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