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PLM-101

Catalog No. T78871

PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, contributing to its anti-leukemic effects. The compound's antitumor efficacy is demonstrated in both a mouse MV4-11 flank xenograft model (doses of 3 and 10 mg/kg; po) and an allogeneic xenograft mouse model (dose of 40 mg/kg; po) [1].

PLM-101

PLM-101

Catalog No. T78871
PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, contributing to its anti-leukemic effects. The compound's antitumor efficacy is demonstrated in both a mouse MV4-11 flank xenograft model (doses of 3 and 10 mg/kg; po) and an allogeneic xenograft mouse model (dose of 40 mg/kg; po) [1].
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Product Introduction

Bioactivity
Description
PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, contributing to its anti-leukemic effects. The compound's antitumor efficacy is demonstrated in both a mouse MV4-11 flank xenograft model (doses of 3 and 10 mg/kg; po) and an allogeneic xenograft mouse model (dose of 40 mg/kg; po) [1].
In vitro
PLM-101 at concentrations of 30 nM and 100 nM inhibits the phosphorylation of AKT (phospho-S473) and p70S6K (phospho-T389) within the PI3K signaling pathway, as well as the phosphorylation of MEK (phospho-S217/S221) and ERK (phospho-T202/Y204) in the Ras signaling pathway [1].
Chemical Properties
Molecular Weight407.44
FormulaC22H22FN5O2
Storage & Solubility Information
StorageShipping with blue ice.

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