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PNB-001

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Catalog No. T87227Cas No. 1528760-09-9

PNB-001 is an orally active, CCK2-selective ligand and antagonist with anti-inflammatory and analgesic activities [1].

PNB-001

PNB-001

😃Good
Catalog No. T87227Cas No. 1528760-09-9
PNB-001 is an orally active, CCK2-selective ligand and antagonist with anti-inflammatory and analgesic activities [1].
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
PNB-001 is an orally active, CCK2-selective ligand and antagonist with anti-inflammatory and analgesic activities [1].
In vitro
PNB-001 (100 nM, 30 min) effectively inhibits the contraction of the duodenum in experimental rats induced by CCK4 and CCK5 [1].
In vivo
PNB-001, administered orally at doses of 5 and 20 mg/kg, exhibits anti-inflammatory activity and protects rats from ulcers induced by indomethacin [1].
Chemical Properties
Molecular Weight313.78
FormulaC18H16ClNO2
Cas No.1528760-09-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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