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Pomalidomide-amido-PEG3-C2-NH2
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Catalog No. T18553Cas No. 2328070-52-4
Alias E3 ligase Ligand-Linker Conjugates 55, Cereblon Ligand-Linker Conjugates 22
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]
Pomalidomide-amido-PEG3-C2-NH2
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Catalog No. T18553Alias E3 ligase Ligand-Linker Conjugates 55, Cereblon Ligand-Linker Conjugates 22Cas No. 2328070-52-4
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $79 | 5 days | |
| 5 mg | $128 | Backorder |
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Chemical Properties
| Description | Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1] |
| In vitro | Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) is a precursor for synthesizing BI-3663, a cereblon-based molecule that degrades focal adhesion tyrosine kinase (PTK2) in human hepatocellular carcinoma (HCC) cell lines. It achieves over 80% degradation in 11 HCC cell lines, with a median DC50 of 30 nM[1]. |
| Alias | E3 ligase Ligand-Linker Conjugates 55, Cereblon Ligand-Linker Conjugates 22 |
| Molecular Weight | 476.48 |
| Formula | C22H28N4O8 |
| Cas No. | 2328070-52-4 |
| Relative Density. | 1.388 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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