Shopping Cart
- Remove All
![TargetMol](https://newstatic.targetmol.com/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $79 | 5 days | |
5 mg | $128 | Backorder |
Description | Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1] |
In vitro | Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) serves as a precursor for the synthesis of BI-3663, a cereblon-based molecule that effectively degrades focal adhesion tyrosine kinase (PTK2) in human hepatocellular carcinoma (HCC) cell lines. It demonstrates potent activity, achieving more than 80% degradation across a panel of 11 HCC cell lines, with a median DC50 of 30 nM[1]. |
Alias | Cereblon Ligand-Linker Conjugates 22, E3 ligase Ligand-Linker Conjugates 55 |
Molecular Weight | 476.48 |
Formula | C22H28N4O8 |
Cas No. | 2328070-52-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.