Name: POP-IN-1
Brand: TargetMol
SKU: T61906
Rating: 4.5 (1 reviews)

POP-IN-1

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Catalog No. T61906Cas No. 2743432-99-5

POP-IN-1 (Compound 12h) is an effective POP inhibitor (Ki=0.009 μM) with research potential in neurodegenerative diseases and cancer progression.

Pack Size	Price	Availability
25 mg	$2,140	6-8 weeks
50 mg	$2,785	6-8 weeks
100 mg	$3,520	6-8 weeks

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QHow long does sonication usually take?

AThe sonication time depends on the amount and concentration of the substance

QCan the inhibitor DMSO stock solution be directly diluted with buffer to create a gradient?

AIn most cases, it can dissolve. However, sometimes organic reagents may precipitate when directly added to an aqueous medium. It is recommended to first dilute the inhibitor with DMSO to form a gradient, and then add the diluted inhibitor to the buffer or cell culture medium. Some inhibitors may only dissolve in the aqueous phase at their working concentrations. For example, if a final concentration of 1 μM is desired in cell experiments, the 10 mM DMSO stock solution can be diluted to 1 mM with DMSO, and then 2 μL can be drawn and added to 2 mL of saline/PBS/cell culture medium, resulting in a final concentration of 1 μM. To avoid precipitation of the drug, it is recommended to preheat the mother liquor and culture medium to 37°C before dilution to avoid serious precipitation caused by low temperature. If precipitation occurs during the dilution process, it is suggested to use ultrasonic heating to redissolve the compound.

QWhether sonication is needed for product dissolution? What if I don't have an ultrasound machine?

Asonication can accelerate dissolution. If the compound is not dissolving, sonication is recommended. If you don't have an ultrasound machine, a lower solvent concentration or using less powder are recommended.

QHow to deal with the insoluble impurities in the product?

AInsoluble impurities, which do not affect the product activity, are recommended to filter out or remove. We will investigate to confirm whether the impurity was introduced during packaging or if it is inherent to the product itself.

QWhere can I find purity infomation for future products?

AFor futures products, no purity information or quality inspection can be available. Once the products are available, we will conduct quality inspections to determine the purity and structural information, which will be displayed on our official website.

Product Introduction

Bioactivity

Description

POP-IN-1 (Compound 12h) is an effective POP inhibitor (Ki=0.009 μM) with research potential in neurodegenerative diseases and cancer progression.

Chemical Properties

Molecular Weight	399.35
Formula	C₂₂H₃₀BNO₃S
Cas No.	2743432-99-5

Storage & Solubility Information

Storage

Shipping with blue ice.

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.