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PPADS
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Catalog No. T89112Cas No. 149017-66-3
PPADS is a P2 receptor antagonist with IC50 values of 68 nM (P2X1) and 214 nM (P2X3). This compound functions as an ATP (nucleotide) analog, competing for binding sites on the P2 receptors with ATP. Additionally, PPADS acts as a reversible competitive antagonist of the NAADP receptor. It is capable of reversing hyperalgesia, and it diminishes the enhanced NO/NOS signaling and IL-1β production in both peripheral and central steps of the nervous system.
PPADS
😃Good
Catalog No. T89112Cas No. 149017-66-3
PPADS is a P2 receptor antagonist with IC50 values of 68 nM (P2X1) and 214 nM (P2X3). This compound functions as an ATP (nucleotide) analog, competing for binding sites on the P2 receptors with ATP. Additionally, PPADS acts as a reversible competitive antagonist of the NAADP receptor. It is capable of reversing hyperalgesia, and it diminishes the enhanced NO/NOS signaling and IL-1β production in both peripheral and central steps of the nervous system.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PPADS is a P2 receptor antagonist with IC50 values of 68 nM (P2X1) and 214 nM (P2X3). This compound functions as an ATP (nucleotide) analog, competing for binding sites on the P2 receptors with ATP. Additionally, PPADS acts as a reversible competitive antagonist of the NAADP receptor. It is capable of reversing hyperalgesia, and it diminishes the enhanced NO/NOS signaling and IL-1β production in both peripheral and central steps of the nervous system. |
| Targets&IC50 | P2X2 Receptor:214 nM, p2x1 Receptor:68 nM |
| Molecular Weight | 511.38 |
| Formula | C14H14N3O12PS2 |
| Cas No. | 149017-66-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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