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PPARα/γ agonist 4

Name: PPARα/γ agonist 4
Brand: TargetMol
SKU: T89021
Price: 238 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T89021

Compound (S)-7, also known as PPARα/γ agonist 4, is a dual potent agonist for PPARα and PPARγ with EC50 values of 0.061 μM and 1.42 μM, respectively. This compound exhibits oral efficacy and operates through an insulin-independent mechanism, featuring mitochondrial pyruvate carrier inhibition and antidiabetic properties. PPARα/γ agonist 4 holds potential for research in dyslipidemic type 2 diabetes.

PPARα/γ agonist 4

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Catalog No. T89021

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Product Introduction

Bioactivity

Description	Compound (S)-7, also known as PPARα/γ agonist 4, is a dual potent agonist for PPARα and PPARγ with EC50 values of 0.061 μM and 1.42 μM, respectively. This compound exhibits oral efficacy and operates through an insulin-independent mechanism, featuring mitochondrial pyruvate carrier inhibition and antidiabetic properties. PPARα/γ agonist 4 holds potential for research in dyslipidemic type 2 diabetes.
In vitro	PPARα/γ agonist 4 (100 nM, 24 hours) enhances glucose uptake and metabolism in the C2C12 cell line and prevents lipid accumulation in liver or muscle cells by boosting mitochondrial activity associated with fatty acid degradation.
In vivo	Compound PPARα/γ agonist 4, administered orally at doses of 25 mg/kg and 50 mg/kg over a 15-day treatment period, exhibits dose-dependent antihyperglycemic effects and significant lipid-lowering properties in a diabetic mouse model.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc