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PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM. |
In vitro | PRMT5-IN-41 (compound 130) (0-10000 nM) demonstrates antiproliferative activity, with IC50 values of 5.8 µM and 1291.6 µM against HCT116 MTAP(-/-) and HCT116 WT cells, respectively. |
In vivo | The bioavailability of PRMT5-IN-41 in ICR mice is observed to be 77.5% by oral administration, with half-lives of 4.5 hours for intravenous injection and 3.34 hours for oral consumption when administered at doses of 3 mg/kg (i.v.) and 10 mg/kg (p.o.), respectively. |
Molecular Weight | 477.39 |
Formula | C22H16F5N5O2 |
Cas No. | 3034034-32-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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