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Prostaglandin D2 Ethanolamide

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Catalog No. T38389Cas No. 398138-28-8
Alias Prostaglandin D2 Ethanolamide

Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.

Prostaglandin D2 Ethanolamide

Prostaglandin D2 Ethanolamide

😃Good
Catalog No. T38389Alias Prostaglandin D2 EthanolamideCas No. 398138-28-8
Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.
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Product Introduction

Bioactivity
Description
Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.
AliasProstaglandin D2 Ethanolamide
Chemical Properties
Molecular Weight395.53
FormulaC22H37NO5
Cas No.398138-28-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 8.30 mg/mL (20.98 mM)
DMSO: 8.30 mg/mL (20.98 mM)
PBS (pH 7.2): 2.50 mg/mL (6.32 mM)
Ethanol: 12.50 mg/mL (31.60 mM)
Solution Preparation Table
PBS (pH 7.2)/DMF/DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.5283 mL12.6413 mL25.2825 mL126.4127 mL
5 mM0.5057 mL2.5283 mL5.0565 mL25.2825 mL
DMF/DMSO/Ethanol
1mg5mg10mg50mg
10 mM0.2528 mL1.2641 mL2.5283 mL12.6413 mL
20 mM0.1264 mL0.6321 mL1.2641 mL6.3206 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Prostaglandin D-2 Ethanolamide
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