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PROTAC AR/AR-V7 degrader-1

Name: PROTAC AR/AR-V7 degrader-1
Brand: TargetMol
SKU: T87256
Price: 111 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T87256Cas No. 2841308-96-9

PROTAC AR/AR-V7 degrader-1 (27c) serves as a dual degrader targeting both AR and AR-V7, showcasing DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. It effectively induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker) [1].

PROTAC AR/AR-V7 degrader-1

😃Good

Catalog No. T87256Cas No. 2841308-96-9

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Product Introduction

Bioactivity

Description	PROTAC AR/AR-V7 degrader-1 (27c) serves as a dual degrader targeting both AR and AR-V7, showcasing DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. It effectively induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker) [1].
In vitro	PROTAC AR/AR-V7 degrader-1 (27c) effectively inhibits the transcriptional activity of the AR signaling pathway. Its IC50 in 22RV1 cells is 0.9 μM [1]. Additionally, PROTAC AR/AR-V7 degrader-1 (27c) overcomes resistance in advanced prostate cancer expressing AR splice variants [1].

Chemical Properties

Molecular Weight	485.43
Formula	C₂₄H₁₉F₄N₅O₂
Cas No.	2841308-96-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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