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PROTAC SMARCA2/4-degrader-6

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Catalog No. T89231Cas No. 2568277-87-0

PROTACSMARCA2/4-degrader-6 (compound I-438) is a degrader of SMARCA2/4, showing potential for use in cancer research.

PROTAC SMARCA2/4-degrader-6

PROTAC SMARCA2/4-degrader-6

😃Good
Catalog No. T89231Cas No. 2568277-87-0
PROTACSMARCA2/4-degrader-6 (compound I-438) is a degrader of SMARCA2/4, showing potential for use in cancer research.
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Product Introduction

Bioactivity
Description
PROTACSMARCA2/4-degrader-6 (compound I-438) is a degrader of SMARCA2/4, showing potential for use in cancer research.
In vitro
PROTAC SMARCA2/4-degrader-6 (compound I-438) induces degradation of SMARCA2 and SMARCA4 proteins in MV4-11 cells at concentrations ranging from 0-1000 nM over 24 hours, with DC50 values for SMARCA2 and SMARCA4 both being less than 100 nM.
Chemical Properties
Molecular Weight928.16
FormulaC50H61N11O5S
Cas No.2568277-87-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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