PTP1B-IN-24

Name: PTP1B-IN-24
Brand: TargetMol
SKU: T87276
Price: 31 USD
Availability: InStock
Rating: 4.5 (1 reviews)

PTP1B-IN-24 (Compound 9), a reversible PTP1B inhibitor, exhibits an IC 50 value of 1.4 μM and can increase the thermal stability of PTP1B. This compound is capable of reversing PA-induced insulin resistance by enhancing the phosphorylation levels of IRS1 and AKT [1].

Catalog No. T87276Cas No. 2221707-61-3

Resource Download

PTP1B-IN-24

Catalog No. T87276Cas No. 2221707-61-3

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	PTP1B-IN-24 (Compound 9), a reversible PTP1B inhibitor, exhibits an IC 50 value of 1.4 μM and can increase the thermal stability of PTP1B. This compound is capable of reversing PA-induced insulin resistance by enhancing the phosphorylation levels of IRS1 and AKT [1].
Targets&IC50	Akt:15 nM
In vitro	PTP1B-IN-24 at concentrations of 0-32 μM for 24 hours does not affect cell viability in LO2 cells. In HepG2 cells, PTP1B-IN-24 at concentrations of 1-2 μM for 24 hours improves PA (0.4 mM; 24 h) induced insulin resistance [1]. Western Blot Analysis indicates that in the HepG2 cell line, with a concentration of 1 μM and 2 μM for an incubation time of 24 hours, the compound enhanced the phosphorylated expression of IRS1 (Y632) and Akt (S473).

Chemical Properties

Molecular Weight	420.44
Formula	C₂₂H₁₆N₂O₅S
Cas No.	2221707-61-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc