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R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $133 | 35 days | |
5 mg | $613 | 35 days | |
10 mg | $1,150 | 35 days | |
25 mg | $2,550 | 35 days |
Description | R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex. |
Molecular Weight | 348.71 |
Formula | C16H8ClF3N4 |
Cas No. | 338773-13-0 |
Relative Density. | 1.55 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 2 mg/mL (5.74 mM), Sonication is recommended. DMF: 16 mg/mL (45.88 mM), Sonication is recommended. DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL (0.46 mM), Sonication is recommended. |
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