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RD3-0028
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Catalog No. T12696Cas No. 3886-39-3
RD3-0028 is a potent and selective RSV replication inhibitor with an EC50 of 4.5 μM.
RD3-0028
😃Good
Catalog No. T12696Cas No. 3886-39-3
RD3-0028 is a potent and selective RSV replication inhibitor with an EC50 of 4.5 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RD3-0028 is a potent and selective RSV replication inhibitor with an EC50 of 4.5 μM. |
| Targets&IC50 | RSV:（EC50）4.5 μM |
| In vitro | RD3-0028 exhibits an effective concentration (EC50) of 4.5 μM and a significantly lower cytotoxicity, with a 50% cytotoxic concentration (CC50) of 271.0μM, outperforming ribavirin. It lacks inhibitory effects on the replication of measles virus, influenza A virus, herpes simplex virus types 1 and 2, and human cytomegalovirus. However, RD3-0028 effectively inhibits various RSV strains at concentrations ranging from 4.5 to 11.0 μM, as determined by the MTT method, demonstrating superior efficacy to ribavirin with lower EC50 values against these strains[1]. |
| In vivo | Aerosols from reservoirs containing RD3-0028 (7 mg/mL; 2 h twice daily for 3 days) significantly reduce the pulmonary titer in RSV-infected mice, demonstrating that the minimal effective dose of RD3-0028 is considerably less than that of ribavirin, the only compound currently available for RSV disease. |
| Molecular Weight | 168.28 |
| Formula | C8H8S2 |
| Cas No. | 3886-39-3 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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