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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | RD3-0028 is a potent and selective RSV replication inhibitor(EC50 of 4.5 μM). |
In vitro | RD3-0028 exhibits an effective concentration (EC50) of 4.5 μM and a significantly lower cytotoxicity, with a 50% cytotoxic concentration (CC50) of 271.0μM, outperforming ribavirin. It lacks inhibitory effects on the replication of measles virus, influenza A virus, herpes simplex virus types 1 and 2, and human cytomegalovirus. However, RD3-0028 effectively inhibits various RSV strains at concentrations ranging from 4.5 to 11.0 μM, as determined by the MTT method, demonstrating superior efficacy to ribavirin with lower EC50 values against these strains[1]. |
In vivo | Aerosols generated from reservoirs containing RD3-0028 (7 mg/mL; 2 h twice daily for 3 days) significantly reduces the pulmonary titer of RSV-infected mice.?It is clear that the minimal effective dose of RD3-0028 for RSV-infected mice is significantly less than that of ribavirin, the only compound currently available for use against RSV disease. |
Molecular Weight | 168.28 |
Formula | C8H8S2 |
Cas No. | 3886-39-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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