RGH-560 (compound 53) exhibits highly advanced α7 nAChR positive modulation, favorable physicochemical properties, and robust in vivo procognitive potential. It is useful for studying Scopolamine-induced amnesia in mice [1].

RGH-560 (compound 53), when administered intraperitoneally at doses of 1 mg/kg, 3 mg/kg, and 10 mg/kg, significantly enhances cognition in mice with scopolamine-induced amnesia. RGH-560 is characterized by moderate clearance and exhibits no toxicity in mice at doses up to 30 mg/kg [1].

Animal Model: Mice with scopolamine-induced amnesia [1]
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Reversed the scopolamine-induced cognitive impairment.