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Rovanersen
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Catalog No. T39479Cas No. 2072901-32-5
Alias WVE-120101, Rovanersen
Rovanersen (WVE-120101) is an antisense oligonucleotide used for Huntington’s disease research.
Rovanersen
😃Good
Catalog No. T39479Alias WVE-120101, RovanersenCas No. 2072901-32-5
Rovanersen (WVE-120101) is an antisense oligonucleotide used for Huntington’s disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $614 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rovanersen (WVE-120101) is an antisense oligonucleotide used for Huntington’s disease research. |
| In vitro | In vitro, Rovanersen (WVE-120101) selectively facilitates RNase H-mediated cleavage of the mutant Huntingtin allele (mHTT) over the wild-type HTT (wtHTT), without activating the complement system. Additionally, Rovanersen specifically reduces mHTT mRNA and protein levels compared to wtHTT across various cell lines[1]. |
| In vivo | In non-human primates (NHPs), Rovanersen (WVE-120101) selectively localizes to the nuclear and perinuclear regions of neurons in brain areas associated with Huntington's disease (HD) pathology[1]. |
| Alias | WVE-120101, Rovanersen |
| Cas No. | 2072901-32-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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