Shopping Cart
- Remove All
Your shopping cart is currently empty
RWJ52353 hydrochloride
😃Good
Catalog No. T87348Cas No. 245744-13-2
RWJ-52353 hydrochloride is a potent oral agonist of the α2D adrenergic receptor (Ki: 1.5 nM) with potential analgesic properties. It exhibits pain-relief activity in abdominal tests on rats and mice and reduces agitation in mice during the hot plate and tail flick tests. Furthermore, RWJ-52353 hydrochloride modulates the organic cation transporter (OCT) subtypes by inhibiting rOCT1 and rOCT2 with IC50 values of 100 μM and 20 μM, respectively, and activating rOCT3, influencing the transport of [3H]-1-methyl-4-phenylpyridinium ([3H]MPP) in cells [1] [2].
RWJ52353 hydrochloride
😃Good
Catalog No. T87348Cas No. 245744-13-2
RWJ-52353 hydrochloride is a potent oral agonist of the α2D adrenergic receptor (Ki: 1.5 nM) with potential analgesic properties. It exhibits pain-relief activity in abdominal tests on rats and mice and reduces agitation in mice during the hot plate and tail flick tests. Furthermore, RWJ-52353 hydrochloride modulates the organic cation transporter (OCT) subtypes by inhibiting rOCT1 and rOCT2 with IC50 values of 100 μM and 20 μM, respectively, and activating rOCT3, influencing the transport of [3H]-1-methyl-4-phenylpyridinium ([3H]MPP) in cells [1] [2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | RWJ-52353 hydrochloride is a potent oral agonist of the α2D adrenergic receptor (Ki: 1.5 nM) with potential analgesic properties. It exhibits pain-relief activity in abdominal tests on rats and mice and reduces agitation in mice during the hot plate and tail flick tests. Furthermore, RWJ-52353 hydrochloride modulates the organic cation transporter (OCT) subtypes by inhibiting rOCT1 and rOCT2 with IC50 values of 100 μM and 20 μM, respectively, and activating rOCT3, influencing the transport of [3H]-1-methyl-4-phenylpyridinium ([3H]MPP) in cells [1] [2]. |
| In vivo | RWJ-52353 (30 mg/kg; po) hydrochloride exhibits complete inhibition (100%) in a mouse model of induced abdominal pain [1]. The ED50 values of RWJ-52353 in induced abdominal pain models for rats and mice are 15.1 mg/kg (po) and 11.6 mg/kg (po), respectively [1]. Additionally, RWJ-52353 alleviates pain in the mouse hot plate test (48°C) and tail-flick test, with ED50 values of 25.9 mg/kg (po) and 100.2 mg/kg (po), respectively [1]. |
| Formula | C11H11ClN2S |
| Cas No. | 245744-13-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy RWJ52353 hydrochloride | purchase RWJ52353 hydrochloride | RWJ52353 hydrochloride cost | order RWJ52353 hydrochloride | RWJ52353 hydrochloride chemical structure | RWJ52353 hydrochloride in vivo | RWJ52353 hydrochloride formula
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.