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SAFit1

Name: SAFit1
Brand: TargetMol
SKU: T16835
Price: 50 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16835Cas No. 1643125-32-9

SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM).

SAFit1

😃Good

Catalog No. T16835Cas No. 1643125-32-9

SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM).

Pack Size	Price	Availability
25 mg	$1,400	8-10 weeks
50 mg	$1,820	8-10 weeks
100 mg	$2,760	8-10 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM).
Targets&IC50	FKBP51:(ki)4±0.3 nM, FKBP52:>50000 nM(ki)
In vitro	SAFit1 is active over a wide concentration range. SAFit1 (1-1000 nM) effectively stimulates neurite outgrowth in two neuronal cell lines as well as in primary hippocampal neurons [1].

Chemical Properties

Molecular Weight	747.87
Formula	C₄₂H₅₃NO₁₁
Cas No.	1643125-32-9
Relative Density.	1.211 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 300 mg/mL (401.14 mM)

MEthanol: 125 mg/mL (167.14 mM), Sonication is recommended.

Solution Preparation Table

MEthanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3371 mL	6.6857 mL	13.3713 mL	66.8565 mL
5 mM	0.2674 mL	1.3371 mL	2.6743 mL	13.3713 mL
10 mM	0.1337 mL	0.6686 mL	1.3371 mL	6.6857 mL
20 mM	0.0669 mL	0.3343 mL	0.6686 mL	3.3428 mL
50 mM	0.0267 mL	0.1337 mL	0.2674 mL	1.3371 mL
100 mM	0.0134 mL	0.0669 mL	0.1337 mL	0.6686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SAFit-1SAFit1