Shopping Cart

Remove All
Your shopping cart is currently empty

sEH/HDAC6-IN-2

Name: sEH/HDAC6-IN-2
Brand: TargetMol
SKU: T88891
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T88891Cas No. 3009011-58-6

sEH/HDAC6-IN-2 is an effective dual inhibitor of soluble epoxide hydrolase (sEH) and HDAC6, demonstrating IC50 values of 0.9 nM for human sEH, 46.8 nM for mouse sEH, and 8 nM for HDAC6. It is used in research focused on inflammatory pain.

sEH/HDAC6-IN-2

😃Good

Catalog No. T88891Cas No. 3009011-58-6

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	sEH/HDAC6-IN-2 is an effective dual inhibitor of soluble epoxide hydrolase (sEH) and HDAC6, demonstrating IC50 values of 0.9 nM for human sEH, 46.8 nM for mouse sEH, and 8 nM for HDAC6. It is used in research focused on inflammatory pain.
Targets&IC50	HDAC2:0.492 μM, HDAC1:1.151 μM, Human sEh:0.0009 μM, Mouse sEh:0.0468 μM, HDAC8:0.062 μM, HDAC6:0.008 μM, HDAC11:0.464 μM, HDAC3:1.276 μM
In vitro	sEH/HDAC6-IN-2 exhibits selective inhibition towards HDAC6, demonstrated by its significant selectivity indices (HDAC1/HDAC6 = 144, HDAC2/HDAC6 = 62, HDAC3/HDAC6 = 160, HDAC8/HDAC6 = 8, HDAC11/HDAC6 = 58). When administered at concentrations of 1-2 μM for 24 hours, sEH/HDAC6-IN-2 (compound 28g) induces an increase in acetylation of α-tubulin without affecting histone H3, indicating a selective inhibition of HDAC6.
In vivo	sEH/HDAC6-IN-2 (compound 28g; 30 mg/kg; intraperitoneal injection; single dose) alleviated inflammation-induced pain in mice following formalin exposure.

Chemical Properties

Molecular Weight	580.02
Formula	C₂₇H₃₂ClF₂N₅O₅
Cas No.	3009011-58-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc