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SHP2-IN-14

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Catalog No. T79108Cas No. 2673400-91-2

SHP2-IN-14 (compound 27) is a potent, orally active allosteric inhibitor of SHP2 with an IC50 of 7 nM, exhibiting strong anti-tumor activity, inhibiting tumor progression in NCI-H358 tumor-bearing mice, and demonstrating favorable pharmacokinetic properties and safety [1].

SHP2-IN-14

SHP2-IN-14

😃Good
Catalog No. T79108Cas No. 2673400-91-2
SHP2-IN-14 (compound 27) is a potent, orally active allosteric inhibitor of SHP2 with an IC50 of 7 nM, exhibiting strong anti-tumor activity, inhibiting tumor progression in NCI-H358 tumor-bearing mice, and demonstrating favorable pharmacokinetic properties and safety [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,9708-10 weeks
50 mg$2,5808-10 weeks
100 mg$3,4008-10 weeks
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Product Introduction

Bioactivity
Description
SHP2-IN-14 (compound 27) is a potent, orally active allosteric inhibitor of SHP2 with an IC50 of 7 nM, exhibiting strong anti-tumor activity, inhibiting tumor progression in NCI-H358 tumor-bearing mice, and demonstrating favorable pharmacokinetic properties and safety [1].
Chemical Properties
Molecular Weight483.35
FormulaC22H20Cl2N8O
Cas No.2673400-91-2
Storage & Solubility Information
StorageShipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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