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SHP2-IN-31

Catalog No. T89411Cas No. 2411321-35-0

SHP2-IN-31 is an SHP2 inhibitor with an IC50 value of 13 nM (wild-type SHP2), >10000 nM (SHP1), and >10000 nM (SHP2 E76K). This compound effectively inhibits pERK in a variety of tumor cells and suppresses tumor growth in xenograft models driven by RTK/KRAS.

SHP2-IN-31

SHP2-IN-31

Catalog No. T89411Cas No. 2411321-35-0
SHP2-IN-31 is an SHP2 inhibitor with an IC50 value of 13 nM (wild-type SHP2), >10000 nM (SHP1), and >10000 nM (SHP2 E76K). This compound effectively inhibits pERK in a variety of tumor cells and suppresses tumor growth in xenograft models driven by RTK/KRAS.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
SHP2-IN-31 is an SHP2 inhibitor with an IC50 value of 13 nM (wild-type SHP2), >10000 nM (SHP1), and >10000 nM (SHP2 E76K). This compound effectively inhibits pERK in a variety of tumor cells and suppresses tumor growth in xenograft models driven by RTK/KRAS.
Chemical Properties
Molecular Weight437.36
FormulaC21H26Cl2N4O2
Cas No.2411321-35-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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