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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | SIAIS164018, a PROTAC-based ALK and EGFR degrader derived from Brigatinib, exhibits IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It significantly hampers cancer cell migration and invasion, induces G1 cell cycle arrest, and triggers apoptosis, demonstrating superior properties compared to Brigatinib [1]. |
Molecular Weight | 883.33 |
Formula | C43H48ClN10O7P |
Cas No. | 2353492-68-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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