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SID 3712249

SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).

Catalog No. T16882Cas No. 522606-67-3

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SID 3712249

Catalog No. T16882Cas No. 522606-67-3

SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
2 mg	$48	5 days

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Product Introduction

Bioactivity

Description	SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).
In vitro	MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple-negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantation into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking the production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
Alias	MiR-544 Inhibitor 1

Chemical Properties

Molecular Weight	323.4
Formula	C₁₇H₂₁N₇
Cas No.	522606-67-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 16.67 mg/mL (51.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0921 mL	15.4607 mL	30.9215 mL	154.6073 mL
5 mM	0.6184 mL	3.0921 mL	6.1843 mL	30.9215 mL
10 mM	0.3092 mL	1.5461 mL	3.0921 mL	15.4607 mL
20 mM	0.1546 mL	0.7730 mL	1.5461 mL	7.7304 mL
50 mM	0.0618 mL	0.3092 mL	0.6184 mL	3.0921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SID3712249SID-3712249SID 3712249